Common Causes
Allergic Reactions
- Anaphylaxis:
- LIFE-THREATENING EMERGENCY
- Rapid onset (minutes)
- Throat tightness/closing
- Difficulty breathing
- Skin reactions (hives)
- Low blood pressure
- Common triggers: foods, medications, insect stings
- Angioedema:
- Deep tissue swelling
- Face, lips, tongue, throat
- Can be allergic or hereditary
- ACE inhibitor side effect
- May progress rapidly
- Can block airway
- Food allergies:
- Common: nuts, shellfish, eggs
- Oral allergy syndrome
- Throat itching/swelling
- May progress to anaphylaxis
- Drug allergies:
- Antibiotics (penicillin)
- NSAIDs
- Contrast dyes
- Any medication possible
Infections
- Epiglottitis:
- MEDICAL EMERGENCY
- Inflamed epiglottis
- High fever
- Drooling
- Tripod position
- Muffled voice
- More common in children
- Peritonsillar abscess:
- Complication of tonsillitis
- Severe sore throat
- Unilateral swelling
- "Hot potato" voice
- Trismus (jaw spasm)
- Drooling
- Retropharyngeal abscess:
- Deep neck infection
- Neck stiffness
- Difficulty swallowing
- Respiratory distress
- More common in children
- Pharyngitis:
- Viral or bacterial
- Strep throat
- Mononucleosis
- Throat pain and swelling
- Difficulty swallowing
- Ludwig's angina:
- Floor of mouth infection
- Rapidly progressive
- Tongue elevation
- Airway compromise
- Dental origin often
Inflammatory Conditions
- GERD (Acid reflux):
- Chronic throat irritation
- Globus sensation
- Morning throat swelling
- Hoarseness
- Chronic cough
- Laryngopharyngeal reflux:
- Silent reflux
- Throat clearing
- Sensation of lump
- Voice changes
- Thyroiditis:
- Thyroid inflammation
- Front of neck swelling
- Pain with swallowing
- May have fever
Trauma and Foreign Bodies
- Throat injury:
- Blunt or penetrating trauma
- Intubation injury
- Burns (thermal/chemical)
- Post-surgical swelling
- Foreign body:
- Fish bones
- Food impaction
- Pills stuck in throat
- Localized swelling
- Inhalation injury:
- Smoke inhalation
- Chemical fumes
- Steam burns
- Progressive swelling
Tumors and Masses
- Throat cancer:
- Progressive symptoms
- Persistent hoarseness
- Difficulty swallowing
- Neck mass
- Weight loss
- Thyroid masses:
- Goiter
- Thyroid nodules
- Front neck swelling
- Compression symptoms
- Lymphoma:
- Enlarged lymph nodes
- Night sweats
- Fever
- Weight loss
Other Causes
- Hereditary angioedema: Genetic condition, recurrent swelling
- Globus pharyngeus: Sensation of lump, no actual swelling
- Muscle tension: Stress-related throat tightness
- Radiation therapy: Post-treatment swelling
- Sjogren's syndrome: Dry throat, swelling sensation
- Vocal cord dysfunction: Paradoxical movement
Associated Symptoms
Respiratory Symptoms
- Difficulty breathing (dyspnea)
- Stridor (high-pitched breathing)
- Wheezing
- Rapid breathing
- Inability to speak in full sentences
- Use of accessory muscles
- Cyanosis (blue coloring)
Swallowing and Voice
- Difficulty swallowing (dysphagia)
- Painful swallowing (odynophagia)
- Drooling
- Voice changes/hoarseness
- Muffled or "hot potato" voice
- Complete voice loss
Systemic Symptoms
- Fever and chills
- Skin rash or hives
- Facial swelling
- Lip/tongue swelling
- Nausea/vomiting
- Dizziness/lightheadedness
- Rapid heart rate
- Anxiety/panic
Diagnosis and Evaluation
Emergency Assessment
- Airway, breathing, circulation check
- Oxygen saturation monitoring
- Visual inspection of throat
- Assessment of voice quality
- Evaluation for stridor
- Allergy history
Diagnostic Tools
- Direct visualization:
- Careful oral examination
- Flexible laryngoscopy
- Avoid if epiglottitis suspected
- Imaging:
- Lateral neck X-ray
- CT scan for abscess
- Chest X-ray if indicated
- Laboratory tests:
- CBC with differential
- Blood cultures
- Throat culture
- Allergy testing
Treatment Approaches
Emergency Treatment
- Anaphylaxis:
- Epinephrine immediately
- Airway management
- IV fluids
- Antihistamines
- Corticosteroids
- Continuous monitoring
- Airway management:
- Oxygen supplementation
- Positioning
- Intubation if needed
- Cricothyrotomy if severe
Medical Treatment
- Infections:
- Antibiotics (IV or oral)
- Abscess drainage
- Supportive care
- Pain management
- Allergic reactions:
- Antihistamines
- Corticosteroids
- H2 blockers
- Avoidance of triggers
- Inflammatory conditions:
- Proton pump inhibitors
- Lifestyle modifications
- Anti-inflammatory drugs
Supportive Care
- Cool mist humidification
- Throat lozenges
- Warm salt water gargles
- Soft diet
- Adequate hydration
- Voice rest
- Elevation of head
Prevention
- Identify and avoid allergens
- Carry epinephrine if prescribed
- Wear medical alert identification
- Vaccinate against preventable infections
- Practice good oral hygiene
- Manage GERD effectively
- Avoid known triggers
- Read food labels carefully
- Inform healthcare providers of allergies
When to Seek Medical Care
Call 911 Immediately
- Any difficulty breathing
- Feeling of throat closing
- Drooling or inability to swallow
- Stridor or wheezing
- Voice changes with breathing problems
- Facial/tongue swelling
- Known allergen exposure with symptoms
- Blue lips or confusion
Urgent Medical Care (Same Day)
- Severe sore throat with fever
- Difficulty swallowing liquids
- Persistent throat swelling
- One-sided throat swelling
- Neck swelling or stiffness
- Voice changes lasting >24 hours
Schedule Appointment
- Chronic throat discomfort
- Recurrent swelling episodes
- GERD symptoms
- Persistent hoarseness
- Throat swelling with weight loss